Keys Disease Charters 

5.0
(54 reviews)
Recent reports
 
Federally permitted
 Overseas Highway 33000, Big Pine Key, FL 33043, United States–

Keys Disease Charters 

Big Pine Key, FL, United States
–
27 ft
4
5.0
(54 reviews)

Welcome to Big Pine Key, your gateway to the world-class waters of the Lower Florida Keys. Fall and winter bring some of the best fishing of the year. As cooler weather pushes bait and aggressive predators into our waters, we utilize highly specialized techniques to put you directly on the fish.

Whether you want to hunt elite pelagics or pull heavy reef giants out of the wrecks, we have you covered:
• Kite Fishing: We suspend live baits on the surface to trigger spectacular, visual strikes from acrobatic sailfish to hard charging blackfin tuna.
• High-Speed Trolling: dragging gear at higher speeds targeting wahoo, tuna, mackerel and sailfish.
• Live Chumming: Creating a feeding frenzy behind the boat to bring big schools of tuna and sailfish directly to the surface.
• Bottom & Drift Fishing: Dropping baits off the reefs and wrecks for hard-fighting, delicious grouper and snapper (mutton, yellowtail, and mangrove).
From seasoned anglers chasing a trophy to families looking for an unforgettable day on the water, we provide the expert crew and top-tier gear to make it happen. Book your Big Pine Key adventure today!

Welcome to Big Pine Key, your gateway to the world-class waters of the Lower Florida Keys. Fall and winter bring some of the best fishing of the year. As cooler weather pushes bait and aggressive predators into our waters, we utilize highly specialized techniques to put you directly on the fish.

Whether you want to hunt elite pelagics or pull heavy reef giants out of the wrecks, we have you covered:
• Kite Fishing: We suspend live baits on the surface to trigger spectacular, visual strikes from acrobatic sailfish to hard charging blackfin tuna.
• High-Speed Trolling: dragging gear at higher speeds targeting wahoo, tuna, mackerel and sailfish.
• Live Chumming: Creating a feeding frenzy behind the boat to bring big schools of tuna and sailfish directly to the surface.
• Bottom & Drift Fishing: Dropping baits off the reefs and wrecks for hard-fighting, delicious grouper and snapper (mutton, yellowtail, and mangrove).
From seasoned anglers chasing a trophy to families looking for an unforgettable day on the water, we provide the expert crew and top-tier gear to make it happen. Book your Big Pine Key adventure today!

Christopher Harpster
Captain
Christopher Harpster
18 years of experience
ID & credentials verified
responds within an hour

Select date to see availability

Trip date:
Group Size:
November 2026
SuMoTuWeThFrSa
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Group Size
2 adults • 0 children
Change
Almost there...
3 hr
FREE Cancellation 3 days notice
8 hour trip starts at 8:00 AM
Amberjack
Grouper (Goliath)
Permit
Tarpon
+4
US $600
Entire boat: up to 4 people
4 Hour (AM) inshore/reef
FREE Cancellation 3 days notice
4 hour trip starts at 8:00 AM
Barracuda (Great)
Grouper (Goliath)
King Mackerel (Kingfish)
Sailfish
+8
US $700
Entire boat: up to 4 people
4 hr (PM)
FREE Cancellation 3 days notice
4 hour trip starts at 1:00 PM
Barracuda (Great)
Cobia
Dolphin (Mahi Mahi)
Grouper (Goliath)
+8
US $750
Entire boat: up to 4 people
5 hr (am)
FREE Cancellation 3 days notice
5 hour trip starts at 8:00 AM
Amberjack
Dolphin (Mahi Mahi)
Grouper (Goliath)
Permit
+8
US $850
Entire boat: up to 4 people
6 hr bridge/inshore
FREE Cancellation 3 days notice
6 hour trip starts at 8:00 AM
Grouper (Goliath)
Permit
Tarpon
Grouper (Black)
+3
US $850
Entire boat: up to 4 people
6 Hour reef/wreck
FREE Cancellation 3 days notice
6 hour trip starts at 8:00 AM
Cobia
Dolphin (Mahi Mahi)
Grouper (Goliath)
Permit
+8
US $950
Entire boat: up to 4 people
8 Hour reef/wreck
FREE Cancellation 3 days notice
8 hour trip starts at 7:30 AM
Dolphin (Mahi Mahi)
Grouper (Goliath)
Sailfish
Wahoo
+3
US $1,200
Entire boat: up to 4 people
6 hr sailfish/wahoo/tuna
FREE Cancellation 3 days notice
6 hour trip starts at 8:00 AM
Dolphin (Mahi Mahi)
Marlin (Blue)
Sailfish
Wahoo
+1
US $1,200
Entire boat: up to 4 people
8 hour deep sea (mahi-mahi)
FREE Cancellation 3 days notice
8 hour trip starts at 8:00 AM
Dolphin (Mahi Mahi)
Marlin (Blue)
Sailfish
Wahoo
+2
US $1,500
Entire boat: up to 4 people
6 hr cubera snapper/night fish
FREE Cancellation 3 days notice
6 hour trip starts at 8:00 PM
Seasonal trip
Aug 1 - Nov 1
Amberjack
Dolphin (Mahi Mahi)
Grouper (Goliath)
Permit
+8
US $1,500
Entire boat: up to 4 people

Customer reviews

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Rating

5.0
54 reviews
4.9
Boat & equipment
5.0
Captain & crew
5.0
Fishing Experience

Anglers' gallery (177)

What anglers say

100%
Great experience
97%
Family friendly
100%
Friendly captain
100%
Good boat
98%
Recommended
100%
Caught fish

All reviews (54)

Frequently mentioned
Showing 1 – 5 of 54 reviews
Jonathan Winn
Jonathan Winn
us
Arkansas, US
Member since 2026
5.0
Verified
Great Trip!!! Couldn’t ask for any better !!!
6 Hour reef/wreck on May 16, 2026 • 2 adults

What a fishing trip!!! Just like we had dreamed about. My son wanted to catch a huge Mahi Mahi (Dolphin) and that’s exactly what happened. Captain Chris explained how the fishing trip would go and what signs on the water we would be looking for. Within the first hour of searching for signs of Mahi Mahi we landed a huge 54 inch Bull. It took 17 minutes to reel in and Captain Chris guided my son the whole way. It was the experience of a lifetime and it didn’t end there!!! We ended up catching a huge nurse shark, many yellowtail snapper, a couple remora and another I can’t remember the name of.

Reported catch:
Dolphin (Mahi Mahi)
Yellowtail Snapper
Christopher Harpster
Response from Captain

Thank you for the review, Jon and thanks for choosing Keys Disease Charters. it was a blast fishing with you and your son. Hope to see you guys back in the future 🎣

Brian Mcquay
Brian Mcquay
Repeat angler
us
Florida, US
Member since 2026
2 trips
5.0
Verified
Legendary captain
4 Hour (AM) inshore/reef on June 29, 2026 • 3 adults • 1 child

Captain Christopher is an absolute legend. If you're looking to land big fish in the keys this is the boat you want to take. We wanted to do some bottom fishing and were not disappointed. At one point we nearly lost a large black grouper. The captain was starting to gear up to jump in after him! He wasn't about to let us lose that catch. Highly recommend this boat if you want to catch some monster fish with perhaps the most legendary boat captain in the keys.

Reported catch:
Black Grouper
King Mackerel (Kingfish)
Yellowtail Snapper
Matt Thede
Matt Thede
Member since 2026
5.0
Awesome Trip with Captain Chris!
4 hr (PM) on January 10, 2026

From the very start of the trip, Chris was great with communication and setting up our group to be successful. I had six high school students who wanted to fish with two adults, so he was absolutely fantastic and making sure we had a great experience. He spent his morning catching us bait so that when we arrived for our 1 o'clock arrival time, we were already set up for success. When on the boat, he was friendly, personal, and related with all of us. He made sure that we had everything we needed when we needed it. At the first location, we ended up catching some mackerel and snapper for supper, and then headed out to deeper Waters to try for some tuna and sailfish. He put us in the right spot and it wasn't long before the tuna were boiling at the surface and we had multiple fish on at one time. He did not get frustrated at us when our fishing skills were lacking. Instead, he instructed us and helped us with the next hook set, helping us be successful....which translated into a bunch of happy customers! I cannot recommend him enough if you are in the Marathon area or Big Pine Key area. Will definitely be looking him up again when we come back!

Reported catch:
Yellowtail Snapper
Blackfin Tuna
Christopher Harpster
Response from Captain

thanks for the review, Matt and thanks for choosing keys disease charters. Had a blast fishing with you guys and hope to see you guys back soon 🎣

William Vernier
William Vernier
Repeat angler
us
Michigan, US
Member since 2019
2 trips
5.0
Verified
Great Charter!
6 hr bridge/inshore on May 14, 2026 • 2 adults

Captain Chris was great. He asked us what we wanted to fish for right off the batt and then he took us to rhe fish. The boat was nice and spacious and handles the inland and off shore waves well. I wanted big fish and that is what I cought. Got two goliath grouper and two sharks! Chris was very easy to talk with and answered all the questions we had. Was a very fun day on the water. Highly recommend the 6hr trip.

Reported catch:
Goliath Grouper
Mutton Snapper
Yellowtail Snapper
Christopher Harpster
Response from Captain

thanks for the review william and thanks for choosing Keys Disease Charters. had a blast fishing with you and your wife and would love to have you back in the future 🎣

Aaron Lorentz
Aaron Lorentz
Repeat angler
us
Ohio, US
Member since 2022
7 trips
5.0
Verified
Excellent Day…we’ll be back!
6 Hour reef/wreck on January 2, 2026 • 2 adults

My son (16) and I had a great day on the water with Captain Chris. My son wanted to get on tarpon. Although it wasnt the greatest time of year dor tarpon, TARPON ON! Unfortunately they threw the hook but we witnessed some amazing aerials and got some great video. After a few hours, Captain Chris took us out to a wreck and we werw constantly on fish - Blue Runners, Jack Crevalle, Baracuda, and a Goliath Grouper. It was a great adventure and we’ll definitely be back! Thank you, Captain Chris!

Reported catch:
Goliath Grouper
Tarpon
Christopher Harpster
Response from Captain

thanks for the review aaron and thanks for choosing keys disease charters! we look forward to having you back on the water soon 🎣

FAQs about Keys Disease Charters

Keys Disease Charters offers the following trips to customers:
  • US $600 per group - 3 hr (8 hours)
  • US $700 per group - 4 Hour (AM) inshore/reef (4 hours)
  • US $750 per group - 4 hr (PM) (4 hours)
  • US $850 per group - 5 hr (am) (5 hours)
  • US $850 per group - 6 hr bridge/inshore (6 hours)
  • US $950 per group - 6 Hour reef/wreck (6 hours)
  • US $1,200 per group - 6 hr sailfish/wahoo/tuna (6 hours)
  • US $1,200 per group - 8 Hour reef/wreck (8 hours)
  • US $1,500 per group - 6 hr cubera snapper/night fish (6 hours)
  • US $1,500 per group - 8 hour deep sea (mahi-mahi) (8 hours)
When you book a trip with Keys Disease Charters, you can expect the following amenities onboard:
  • GPS
  • Fishfinder
  • Snorkeling equipment
  • Live bait well
  • Multimedia system
  • Outriggers
  • Tuna tubes
  • Spearfishing equipment
  • Ice box
  • Radar
Trips booked with Keys Disease Charters include:
  • Rods, reels & tackle
  • Live bait (Yes)
  • Lures
  • Catch cleaning & filleting (Cleaning and bagging fish is included in the trip price)
  • Drinks (Water)
  • Fishing license (Fishing licenses are included in the trip cost)
Keys Disease Charters offers the following types of fishing:
  • Inshore fishing
  • Nearshore fishing
  • Offshore fishing (30 miles)
  • Reef fishing
  • Wreck fishing
Keys Disease Charters offers the following fishing techniques:
  • Light tackle
  • Trolling
  • Spinning
  • Jigging
  • Kite fishing
  • Deep sea fishing
Top targeted fish species with Keys Disease Charters include:
  • Amberjack
  • Dolphin (Mahi Mahi)
  • Grouper (Black)
  • Grouper (Goliath)
  • Grouper (Red)
  • Permit
  • Sailfish
  • Snapper (Mutton)
  • Snapper (Yellowtail)
  • Tarpon
  • Tuna (Blackfin)
  • Wahoo

Your captain

Christopher Harpster
Christopher Harpster
Big Pine Key, Florida, United States
36 Fishing Reports
ID & license verified
54 Customer reviews
Typical response within an hour
Member since January 2025
Angler's Choice
The Angler's Choice Award is given to listings that consistently deliver a high-quality service and earn great reviews from customers.
I became an angler because of a lifelong passion for fishing that started in my childhood. Spending time outdoors, connecting with nature, and the thrill of the catch all drew me in. Over time, this hobby grew into a deeper appreciation for the craft and the ecosystem around it and i wanted to share that experience with others. What drives me to work in this business is the opportunity to share that passion with others, whether through guiding, education, or providing quality gear. I love helping people experience the joy and peace that fishing brings, and being part of a community that values sustainability and respect for nature keeps me motivated every day.
Our Team
Charter C.
Charter C.
Business partner
justin c.
justin c.
Captain
Christopher Harpster
Christopher Harpster
Fully verified
Angler's Choice
36
reports
54
reviews
2025
member since
~1h
response
I became an angler because of a lifelong passion for fishing that started in my childhood. Spending time outdoors, connecting with nature, and the thrill of the catch all drew me in. Over time, this hobby grew into a deeper appreciation for the craft and the ecosystem around it and i wanted to share that experience with others. What drives me to work in this business is the opportunity to share that passion with others, whether through guiding, education, or providing quality gear. I love helping people experience the joy and peace that fishing brings, and being part of a community that values sustainability and respect for nature keeps me motivated every day.
The crew
Charter C.
Charter C.
Business partner
justin c.
justin c.
Captain

The fish you can target

Amberjack
Amberjack
Dolphin (Mahi Mahi)
Dolphin (Mahi Mahi)
Black Grouper
Black Grouper
Goliath Grouper
Goliath Grouper
Red Grouper
Red Grouper
Permit
Permit
Sailfish
Sailfish
Mutton Snapper
Mutton Snapper
Yellowtail Snapper
Yellowtail Snapper
Tarpon
Tarpon
Blackfin Tuna
Blackfin Tuna
Wahoo
Wahoo
Amberjack
Amberjack
Dolphin (Mahi Mahi)
Dolphin (Mahi Mahi)
Black Grouper
Black Grouper
Goliath Grouper
Goliath Grouper
Red Grouper
Red Grouper

Real catches by this captain

  • Teen angler holding a large barracuda aboard a center-console fishing boat offshore.
    Fish 1
    Fish 2
    +1
    Great Barracuda
    Kim M.
    Kim M.
    If your looking for a great fishing experience with a knowledgable captain stop looking any further and just book with Keys Disease! Caught barracuda, nurse shark, yellow tail and more!
  • Solo angler proudly holding a large mottled grouper aboard a fishing boat offshore, with rods and a red fish bucket visible.
    Fish 1
    Fish 2
    +4
    Goliath Grouper
    Summer
  • Angler proudly displaying a large Goliath Grouper while fishing offshore, showcasing a successful day on the water.
    Fish 1
    Fish 2
    +1
    Goliath Grouper
    Kris K.
    Kris K.
    Best fishing charter I’ve ever been on hands down, captain Chris is an expert fisherman, lots of knowledge, great stories, and always gives advice or tips if you need it
  • Angler proudly displaying a large Snapper while fishing at night, showcasing a successful catch on the boat.
    Fish 1
    Fish 2
    +1
    Cubera Snapper
    Night time cubera fishing
  • Adult angler holding a colorful mahi-mahi aboard a fishing boat in open ocean waters.
    Fish 1
    Dolphin (Mahi Mahi)
    Keith B.
    Keith B.
    Took a 6 hour Mahi trip, Captain Chris was incredible. Very hardworking Captain and very knowledgeable. Put us right on the fish. Great day
  • Two anglers proudly displaying a large Wahoo caught during a deep-sea fishing trip.
    Fish 1
    Fish 2
    +1
    Dolphin (Mahi Mahi)
    Great summer bite, seeing quality mahi offshore
  • Two anglers proudly displaying a vibrant Mahi Mahi while fishing offshore, showcasing a successful day on the water.
    Fish 1
    Dolphin (Mahi Mahi)
    Bob B.
    Bob B.
  • Solo angler holding a large grouper aboard a fishing boat offshore under clear blue skies.
    Fish 1
    Fish 2
    +4
    Black Grouper
    Brian M.
    Brian M.
    Captain Christopher is an absolute legend. If you're looking to land big fish in the keys this is the boat you want to take. We wanted to do some bottom fishing and were not disappointed. At one point we nearly lost a large black grouper. The captain was starting to gear up to jump in after him! He wasn't about to let us lose that catch. Highly recommend this boat if you want to catch some monster fish with perhaps the most legendary boat captain in the keys.
  • Two anglers hold a large wahoo aboard a center-console boat offshore, showcasing a striped pelagic catch.
    Fish 1
    Fish 2
    Dolphin (Mahi Mahi)
    Melissa T.
    Melissa T.
    We booked an 8 hour mahi trip, family of 4 with 2 teens. My son and husband were looking for bigger fish. We came home with lots of Mahi, a wahoo and lots of good memories . Chris even gave us some tips on how to make dinner. If we get back to the Keys will definitely do this again.
  • Two anglers proudly displaying their catch of Mahi Mahi while fishing in open waters, showcasing a sunny day on the boat.
    Fish 1
    Dolphin (Mahi Mahi)
    Heath C.
    Heath C.

What is the boat like?

Boat image
Boat category
Center console boats
Capacity
4 persons
Boat length
27 ft
Year built
2000
Restored in
2025
Boat manufacturer
Ocean master
Boat type
Center console
Engine model
Mercury
Powered by
1 x 350HP
Max cruising speed
40 knots

What kind of fishing will you do?

Inshore Fishing
Nearshore Fishing
Offshore Fishing
Reef Fishing
Wreck Fishing

Which fishing techniques you can try

Light Tackle
Trolling
Spinning
Jigging
Kite Fishing
Deep Sea Fishing

Which amenities are available onboard

GPS
Fishfinder
Snorkeling equipment
Live bait well
Multimedia system
Outriggers
Tuna tubes
Spearfishing equipment
Ice box
Radar
What's included in the trip price
Rods, reels & tackle
Live bait
Yes
Lures
Catch cleaning & filleting
Cleaning and bagging fish is included in the trip price
Drinks
Water
Fishing license
Fishing licenses are included in the trip cost

How cancellations work

Free cancellation up to 3 days prior to trip
You can cancel or modify your booking up to 3 days before the trip date, free of charge. If you cancel or modify your booking later, or fail to show up, you'll forfeit 100% of what you've paid.
More details

What the listing policies are

Pickup not included
Transfer to/from departure site is not included in trip rates.
Child friendly
Kids are more than welcome. 4 child life jackets on board
You keep catch
Catch and release allowed

How you can pay

Pay online in full
Pay online in full through FishingBooker and save on credit card fees at the dock.
No additional fees.
Book with 10% deposit, pay rest to captain
When the captain confirms your trip, FishingBooker charges your credit card a 10% deposit to guarantee your reservation.
The remaining balance is to be paid directly to the charter operator on or prior to your trip date in one of the following payment methods:
 Cash
 Visa
 Mastercard
 American Express
 PayPal
 Checks
When paying the remaining balance with a credit card, an additional 3.5% charge will apply.

What’s biting in Big Pine Key right now

AmberjackAmberjack
Dolphin (Mahi Mahi)Dolphin (Mahi Mahi)
Grouper (Black)Grouper (Black)
Grouper (Red)Grouper (Red)
PermitPermit
SailfishSailfish
Snapper (Mutton)Snapper (Mutton)
Snapper (Yellowtail)Snapper (Yellowtail)
TarponTarpon
Tuna (Blackfin)Tuna (Blackfin)
WahooWahoo

Compare similar fishing charters

Current
Keys Disease Charters
Keys Disease Charters
Federally permitted
5.0
(54)
27 ft
Group size 1 - 4
1 - 4
Fish 1
Fish 2
+10
4 hour trip • 4 persons
US $700